4.4. Antipyretic Activity
The intraperitoneally administered AEZZ and EEZZ, at the doses of 25, 50, and 100 mg/kg, were reported to exert antipyretic activity when assessed for 8 h using the Brewer’s yeast-induced pyrexia test [44]. Both extracts demonstrated dose-dependent antipyretic effect with the EEZZ significantly reducing the rat’s rectal temperature only at the doses of 50 and 100 mg/kg while the AEZZ was effective at all doses used. Unfortunately, the antipyretic potential of both extracts was not compared against any standard reference drugs.