The risks associated with the pharmacological effects of
melanocortin analogs are unclear. To date, facial flushing,
nausea, and vomiting have been reported.102 However, one
of the major concerns is that these substances are not
specific to the melanocortin receptor and interact with
other physiologic systems. Moreover, some authors have
reported the development of eruptive melanocytic nevi in
patients who had self-administered injections of melanotan
over a period of weeks.103-106