Objective: Aspirin is generally used in the prevention of thrombotic occlusive events such as coronary heart and stroke. Underlying mechanism of action is that aspirin inhibits platelets by inactivating cyclooxygenase-1, thereby blocking the generation of thromboxane A2 which is a potent vasoconstrictor and platelet agonist. Aspirin may also help to decrease the progression of atherosclerosis by its antioxidant effect in addition to its inhibiting effect on the coagulation system. The aim of this study was to examine the antioxidant effect of low-dose aspirin supplementation in a short term period