Intraductal neoplasm of the intrahepatic bile duct
This type is usually seen in the intrahepatic large bile ducts and similar lesions are seen in the hilar and extrahepatic bile ducts.
Intraductal papillary neoplasm of bile duct: This tumor shows a spectrum from preneoplastic lesion to non-invasive and invasive carcinoma, and intraductal papillary neoplasm of bile duct (IPNB) of carcinoma corresponds to the IG type of ICC grossly. In the dilated bile duct it shows papillary growth which is grossly visible[5,9]. Histologically, it is a well-differentiated papillary adenocarcinoma which is invasive or non-invasive while some IPNB can be recognized as a preneoplastic borderline lesion (Figure (Figure4A).4A). Intraductal, intraepithelial spread involving the large bile ducts and even small bile ducts is found variably and constantly. IPNB shows four phenotypes: pancreatobiliary type, oncocytic type, gastric type and intestinal type[14,26]. Clinicopathologically, IPNB is classified into a papillomatosis or papilloma type, intraductal growing type, mucin-producing type and cystic type[14,26]. The bile duct affected by IPNB shows variable dilatation, not infrequently cystic dilatation. Such cystic type should be differentiated from a hepatobiliary mucinous cystic neoplasm (MCN) in which an ovarian-like stroma is detectable in the wall of the cystic tumor[14,26] and the mucin-producing type shows massive mucin secretion. At the invasion site of IPNB, mucinous carcinoma and more frequently conventional tubular adenocarcinoma are found[5,6].
Figure 4
Figure 4
Intraductal type of intrahepatic cholangiocarcinoma. A: Intraductal papillary neoplasm of bile duct. Neoplastic biliary epithelia show papillary growth in the dilated lumen. There is no invasion into the duct wall; B: Intraductal tubular neoplasm of bile ...
Intraductal tubular neoplasm of bile duct: This type is occasionally encountered in the intrahepatic large bile duct[27]. The neoplasm is mainly composed of a tubular component and focally papillary. Mucin secretion is usually absent and appears as a cast in the slightly dilated bile duct (Figure (Figure4B,4B, ,C).C). Intraductal tubular neoplasm of bile duct (ITNB) also shows a spectrum from preneoplastic lesion to carcinoma, even within the same tumor.
Intraductal neoplasm of the intrahepatic bile ductThis type is usually seen in the intrahepatic large bile ducts and similar lesions are seen in the hilar and extrahepatic bile ducts.Intraductal papillary neoplasm of bile duct: This tumor shows a spectrum from preneoplastic lesion to non-invasive and invasive carcinoma, and intraductal papillary neoplasm of bile duct (IPNB) of carcinoma corresponds to the IG type of ICC grossly. In the dilated bile duct it shows papillary growth which is grossly visible[5,9]. Histologically, it is a well-differentiated papillary adenocarcinoma which is invasive or non-invasive while some IPNB can be recognized as a preneoplastic borderline lesion (Figure (Figure4A).4A). Intraductal, intraepithelial spread involving the large bile ducts and even small bile ducts is found variably and constantly. IPNB shows four phenotypes: pancreatobiliary type, oncocytic type, gastric type and intestinal type[14,26]. Clinicopathologically, IPNB is classified into a papillomatosis or papilloma type, intraductal growing type, mucin-producing type and cystic type[14,26]. The bile duct affected by IPNB shows variable dilatation, not infrequently cystic dilatation. Such cystic type should be differentiated from a hepatobiliary mucinous cystic neoplasm (MCN) in which an ovarian-like stroma is detectable in the wall of the cystic tumor[14,26] and the mucin-producing type shows massive mucin secretion. At the invasion site of IPNB, mucinous carcinoma and more frequently conventional tubular adenocarcinoma are found[5,6].รูปที่ 4รูปที่ 4ชนิด Intraductal ของมะเร็งท่อน้ำดี intrahepatic A: Intraductal papillary เนื้องอกของของท่อน้ำดี Neoplastic biliary epithelia แสดงเติบโต papillary ใน lumen โป่ง มีการบุกรุกเข้าไปในผนังท่อ B: Intraductal ท่อเนื้องอกของของน้ำดี...เนื้องอกของท่อ Intraductal ของท่อน้ำดี: ชนิดนี้บางครั้งพบใน intrahepatic ใหญ่ท่อน้ำดี [27] เนื้องอกของเป็นส่วนใหญ่ประกอบด้วยส่วนประกอบท่อ และ focally papillary หลั่ง mucin มักจะขาดงาน และปรากฏเป็นโยนในท่อน้ำดีโป่งเล็กน้อย (รูป (Figure4B, 4B,, C) C) Intraductal เนื้องอกของท่อของท่อน้ำดี (ITNB) แสดงสเปกตรัมจากแผล preneoplastic การ carcinoma แม้ภายในเนื้องอกเหมือนกัน
การแปล กรุณารอสักครู่..
