Topical nonsteroidal anti-inflammatory drugs
Prior studies [33–35] have suggested that NSAIDs
can be used to maintain pupillary dilatation during
surgery, decrease perioperative pain and help
decrease the incidence of postoperative cystoid macular
edema. Although evidence does support the
perioperative use of NSAIDs to prevent CME in
high-risk eyes, there is no published evidence that
routine use results in improved final visual outcomes
[2&&,36&]. Evidence does suggest that NSAIDs
alone or in combination with corticosteroids are
more effective than corticosteroids alone in preventing
and treating acute and chronic CME [37–39]. A
recent prospective randomized clinical study [40&]
reported that both bromfenac 0.09% and nepafenac
0.1% were well tolerated and resulted in positive
outcomes in the treatment of pain and inflammation
after cataract surgery. Regarding duration
of treatment, a recent study by Chatziralli et al. [36&]
points to 4 weeks as an adequate and reasonable
choice for a postoperative treatment interval.