Based on the CQ–imipramine hybrid data, and astemizole antiplasmodial
activity, we were interested in pursuing a hybridization
strategy that combined the core portions of the two structurally
distinct moieties of CQ and astemizole, each of which possess significant
antiplasmodial activities, via an appropriate linker. We
hoped this strategy would result in compounds that could overcome
P. falciparum resistance to CQ, and offer a viable strategy