Scientific evidence has dramatically changed our ideas about the relationships among physical activity, rest, and fatigue. Several studies have reported that exercise can prevent the manifestation of fatigue and reduce its intensity in burn patients during and after treatment. This approach may appear counterintuitive; however, physical activity produces adaptive changes such as gains in muscle mass and plasma volume, improved lung ventilation and perfusion, increased cardiac reserve, and a higher concentration of oxidative muscle enzymes. Furthermore, resistance exercises have been shown to reduce the loss of muscle mass related to corticoid treatment