The performance and suitability of different medium for the soilless culture of tomato plants were studied in a closed soilless culture system employing six different substrates (perlite, pumice, zeolite and their mixtures 1:1 in an glasshouse).The plants grown in medium with salty irrigation water. Tomato leaf analysis showed high concentrations of Ca2+,Mg2+and K+ due to saline water especially in the medium treated with zeolite. The results suggest that the addition of zeolite in perlite and pumice could improve inorganic medium properties for tomato soilless culture, leading to higher yields. The overall results indicated that medium amendment with zeolite could effectively ameliorate salinity stress and improve nutrient balance in the medium