Fig. 3.Expression levels of MRJ-L correlate with HIV-1 viral production. (a, b) Higher expression of MRJ-L increases HIV-1 replication. Macrophages derived from six healthy donors (from
the first cohort study described in Fig. 1) with low or high expression levels of MRJ-L were infected with HIV-1 at (a) high MOI (p24 = 5 ng/mL) and (b) low MOI (p24 = 50 pg/mL),
respectively. Virus output, measured by p24 levels in culture supernatant using ELISA, at day 4 and day 8 after the infection.