With respect to biomarker detection, a series of
innovative high-throughput molecular tests, such as
array-based comparative genome hybridization (aCGH),
single nucleotide polymorphism (SNP) arrays, and next
generation sequencing, have recently been developed
and incorporated into routine clinical practice. The stunning technology replacing speed raised a serious question:
is a classical low-throughput assay, such as FISH, poised
for replacement? However, the answer is quite the opposite. In fact, FISH has become increasingly important
in clinical diagnosis due to its simplicity and reliability
in evaluating key biomarkers in various tumors [5]. In
this article, we aim to review the advances in FISH for
disease biomarker detection and personalized medicine
applications