Safe exposure levels derived from animal studies with assessment
factors of EFSA and ECHA were expectedly much lower than those using the ECETOC approach.
Comparable safe exposure levels were obtained from human data with all sets of assessment factors
while ototoxicity in rats led to major differences. The safe exposure levels finally selected based on
criteria of science and health protection converged to the range of 90–120 mg/person/d. Assuming a consumption
of 1 kg food/d for an adult, this translates to 90 mg styrene migration into 1 kg food as safe for
consumers.