The Blues tackle the Red Devils at Stamford Bridge (5:30pm) and the result could have ramifications for both sides.
Mourinho's side could extend their lead at the top of the table to 10 points with a victory, as Arsenal are in FA Cup semi-final action against Reading (5:20pm).
Though the game presents a serious test of Chelsea's title credentials, Mourinho has been quick to play down the importance of the game.