Discussion
A new fixation and processing module was established
in a study of 1,009 specimens in which cell blocks were
prepared simultaneously from residual material after smear
preparation. The contribution of cell blocks to the diagnosis
also was documented. There is sparse corroborative study in
the literature on the routine use of cell blocks, probably
because of differing emphasis placed on them in various
institutions. Different fixing and processing techniques to
maximize the recovery of cellular material from washings,
tissue fluids, or fine-needle aspirates with various degrees of
expectations make valid comparison difficult. As indicated in
this series we share the view of Zito and others1 that FNAC
sometimes does not yield information for precise diagnosis,
and the risk of false-negative diagnosis and indeterminate
diagnosis is always present. They too observed that although
various authors have reported the use of cell blocks, few
have given sufficient attention to the development of a satisfactory
technique.1
DiscussionA new fixation and processing module was establishedin a study of 1,009 specimens in which cell blocks wereprepared simultaneously from residual material after smearpreparation. The contribution of cell blocks to the diagnosisalso was documented. There is sparse corroborative study inthe literature on the routine use of cell blocks, probablybecause of differing emphasis placed on them in variousinstitutions. Different fixing and processing techniques tomaximize the recovery of cellular material from washings,tissue fluids, or fine-needle aspirates with various degrees ofexpectations make valid comparison difficult. As indicated inthis series we share the view of Zito and others1 that FNACsometimes does not yield information for precise diagnosis,and the risk of false-negative diagnosis and indeterminatediagnosis is always present. They too observed that althoughvarious authors have reported the use of cell blocks, fewhave given sufficient attention to the development of a satisfactorytechnique.1
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