use of antibiotics in the isolated area. L. plantarum 15HN was sensitive
or semi-sensitive to all of the examined antibiotics except for
vancomycin. The strict homo fermentative Lactobacilli are generally
sensitive to vancomycin. However, L. plantarum carries vancomycin
resistance genes [40,70]. L. lactis subsp. lactis 44Lac was resistant to
sulfamethoxazol only.
Probiotics are health-promoting agents that promote different
therapeutic activities, and being anti-carcinogenic is its most
interesting property. Probiotics display high apoptic and antiproliferative
effects on different cancer cell lines (e.g., breast,
bladder, colon, liver, and gastric) [71e76]. The majority of the
literature has focused on their anti-colorectal properties [76e78].
Our results prove that secreted metabolites of L. lactis subsp. Lactis
44Lac have high anti-cancer activities on different cancer cell lines.
Extracted metabolites of this strain showed time-and dosedependent
effects, where 30% (v/v) concentration with50 mg/ml dry
weight after 48 h incubation displayed better results compared
with other concentrations and incubation times.
use of antibiotics in the isolated area. L. plantarum 15HN was sensitiveor semi-sensitive to all of the examined antibiotics except forvancomycin. The strict homo fermentative Lactobacilli are generallysensitive to vancomycin. However, L. plantarum carries vancomycinresistance genes [40,70]. L. lactis subsp. lactis 44Lac was resistant tosulfamethoxazol only.Probiotics are health-promoting agents that promote differenttherapeutic activities, and being anti-carcinogenic is its mostinteresting property. Probiotics display high apoptic and antiproliferativeeffects on different cancer cell lines (e.g., breast,bladder, colon, liver, and gastric) [71e76]. The majority of theliterature has focused on their anti-colorectal properties [76e78].Our results prove that secreted metabolites of L. lactis subsp. Lactis44Lac have high anti-cancer activities on different cancer cell lines.Extracted metabolites of this strain showed time-and dosedependenteffects, where 30% (v/v) concentration with50 mg/ml dryweight after 48 h incubation displayed better results comparedwith other concentrations and incubation times.
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