Distress related to low sexual desire was measured as mean change from baseline to Week 24 in Female Sexual Distress Scale-Revised Item 13 (FSDS-R13 (Distress)). FSDS-R13 (Distress) is a single question from the larger Female Sexual Distress Scale – Revised (FSDS-R (Distress)) instrument which asks “How often did you feel bothered by low sexual desire?” Response choices are “Never, Rarely, Occasionally, Frequently or Always”, scored from 0 t o 4. FSDS-R13 (Distress) was collected using a 7-day recall period. Like the FSFI, the FSDS-R (Distress), including Item 13 has been extensively validated. Copies of the key validation publications for FSDS-R (Distress) are provided in Appendix J.