In 38 global initative for chronic obstructive lung disease stage and 23 healty age-matched controls
Participants underwent a quadriceps
Biopsy
Type 1 and 2 fiber proportion were determined using immunohistochemisty and fibre shift defined using published reference ranges
Calcineurin a phosphorylated AMP kinase
Phospho-AMPK
Subunit
Modulators of calcineurin activity and calmodulin
Were measured by western blotting and myocycle-enriched calcin