Abstract — Worldwide cardiovascular diseases are the major
cause of death. Beside heart transplants, which is a limited option
due to the available number of human donor hearts, artificial
hearts are the only therapy available for terminal heart diseases.
For various reasons a total implantable artificial heart is
desirable. But the limited space in the human thorax sets
rigorous restrictions regarding the weight and the dimensions of
the device. Nevertheless the appropriate functionality of the
artificial heart must be ensured and blood damage must be
prevented. These requirements set further restrictions to the
drive of this device. In this paper two optimization methods,
which are manual parameter variation and Differential
Evolution (DE) algorithm, are presented, to match the
specifications of an artificial heart.