Biological rhythms areimplicated in cardiovascular events. Failure to recognise the
circadian decline in BP may result in iatrogenic chronopathological
events, including anterior ischaemic optic neuropathy
and cerebrovascular accidents. Chronotherapeutics is the
purposeful alteration of drug levels to match rhythms to
optimise therapeutic outcomes and minimise size effects. For
the treatment of hypertension, this idea has the potential for a
therapeutic paradigm shift (Prisant 2001).