The Hippo pathway effector, YAP has been considered an important oncogene (30, 31) that promotes ovarian cancer progression through regulating mechanical transduction (32), ferroptosis (33), and so on. Considering the unique property of PTPA and PP2A described above, we proposed that PDHPS1 may potentially abrogate PP2A-PTPA– mediated activation of YAP to inhibit ovarian cancer progression.