3.4Correlation of solubility data with Yalkowsky model
The logarithmic solubility of crystalline IBR (log xYal) in various ethanol + water cosolvent mixtures was calculated using Eq. (4) according to this model [19]:
LogxYal ¼ m1logx1 þ m2logx2: ð4Þ
In which, x1 and x2 are the mole fraction solubility of crystalline IBR in pure solvent 1 (ethanol) and pure solvent 2 (water), respectively; and m1 and m2 represent the mass fractions of pure solvent 1 and 2 in the absence of crystalline IBR. The resulting data of Yalkowsky model correlation are presented in Table 4. The RMSD values in various ethanol + water cosolvent mixtures were
recorded in the range of (0.96 to 4.09) % which indicated good correlation of experimental solubility data of crystalline IBR with Yalkowsky model.