One of the genes called in question, in particular the 5-HTTLPRอgene, has not been associated only with aggression directed to others or to objects, but also to self-directed aggressiveness, as it was found to be related with suicide risk [66]. The reasons why the same gene may direct aggression toward self or others and which factors may intervene to shift from one to another are currently obscure. However, it should be stressed that the SS allele is not only related to aggression behavior only, but is a depressive behavior marker in various psychiatric conditions [67–74] and encodes also some aspects of obsessive–compulsive behavior in OCD patients [75] and psychotic symptoms in schizophrenia [76].