Disruption of attractive electrostatic configurations by protonation of acidic
residues (pH 3.0) or increased negative charge (pH 6.0) is a likely
cause for this change in low-salt behavior. The concentration
dependence of the amorphous precipitates within the salting-in
region, in conjunction with the apparent irreversibility of formation of
both amorphous aggregate morphologies in their mother liquor,
indicates that there may be a kinetic aspect to this phenomenon that
at present remains elusive.