Endophytes are microorganisms that reside inside the internal
tissues of living plants without causing any symptoms and
obvious harm to the host plants [1]. Endophytes are ubiquitously
found in all plants and are valued for their ability to
synthesize various useful bioactive compounds [2]. These
bioactive compounds were originally involved in defense
mechanisms against phytopathogens [2]. However, in the
recent years, endophytic bioactive compounds were gradually
integrated in novel drug discoveries due to their wide variety
of biological activities as antibiotic, anticancer, antioxidant,
and anti-inflammatory agents [3]. Research on endophytederived
bioactive compounds was escalated with the discovery
of taxol from endophytic Taxomyces andrenae [4]. This anticancer
agent was formerly extracted from the Pacific yew tree,
and with this discovery, more taxol can be produced without
the mass destruction of the yew trees. With the discovery of
taxol-producing endophyte T. andrenae from yew trees, many
researchers hypothesize that endophytes from anticancer
plants have potential to synthesize compounds with anticancer
properties. This prompted investigations on the study of anticancer
compounds produced by various endophytes, such as
campthothecin [5], maytansine [6] and cajanol [7]. In this