To predominate in competitiveness, firms believe that quality information helps them gain competitive advantages and also accomplish their business goals. Therefore, they look around the information processing system implemented to attain their prospects. Based on the resource-based view (RBV) of the firm, firms with the specific resources can be creating their competitive advantage and sustainable performance. This research determines information system (IS) which is applied into organization processes as the specific resources, both valuable assets and embedded capabilities that are the source of expectable outcomes. Beyond information technology resources, this research extensively establishes information orientation construct as an antecedent of competitive advantage and firm performance. Hence, the main research purpose is to empirically investigate the hypothesized relationship between information orientation and competitive advantage. The competitive advantage-firm performance relationship is also examined. In addition, technology growth and industry pressure are addressed as the moderators. Data was collected using mail questionnaires distributed to 500 e-commerce companies. Empirically, 94 completed questionnaires are used in this analysis. As the results, this research finds that information orientation positively affects competitive advantage resulting in the improvement of firm performance, according to the theoretical contributions of RBV. Moreover, the results also reveal that technology growth has a moderating effect on the relationship between information orientation and competitive advantage.