The minimal inhibitory concentrations of chelerythrine (10) for all bacteria and yeasts tested (MIC =1.50 mg/mL, and between 3.12 and 12.5 mg/mL for bacteria and yeasts, respectively), demonstrate that this alkaloid has excellent antimicrobial activity compared to chloramphenicol (3.12 mg/mL for bacteria) and nystatin (between 5.15 to 10.3 mg/mL for yeasts).