[20] proposed a delayed growth-associated model for HA production.
Recently, Liu et al. [21] reported a two-stage culture strategy
model to enhance HA production in either a batch or fed-batch culture.
The batch culture had a higher specific HA synthesis rate, while
the fed-batch culture had a higher specific cell growth rate. The
enhanced HA production by this model resulted from the decreased
inhibition of cell growth and the increased transformation rate of
sucrose to HA.
In this study, mathematical models that described growth, substrate
utilization and inhibition, and HA production were proposed,
taking into account the effect of the initial glucose concentration
on the kinetic parameters. To achieve this goal, experiments were
performed at an initial glucose concentration range of 10–60 g l−1
in the batch fermentation