The
effects of STZ on different organs have been extensively
studied. STZ has various biological actions, including the
production of acute and chronic cellular injury, carcinogenesis,
teratogenesis and mutagenesis (Magee & Swann, 1969). STZ
is a nitrosourea compound which generally shares similar fate
of disposition with other nitrosoureas and is a drug of choice
in islet cell carcinoma and malignant carcinoid tumors.