Despite substantial peer-reviewed and gray literature investigating potential health impacts of climate change, less attention has been paid to adaptation options. While implementation of effective control interventions is the only way to reduce the disease burden of climate change, evaluation of the effectiveness of public health interventions is lacking. As the World Health Organization (WHO) stated “There is a lack of targeted, systematic reviews to identify and assess the effectiveness of interventions to control key climate-sensitive health risks, e.g. for the control of vector-borne diseases or heat health action plans” [9]. Our objective is to address this gap and systematically review existing systematic reviews on the effectiveness of public health interventions to reduce the disease burden of climate change.