Treatment of Bacteremic Mice With Phage pVp-1
The efficacy of phage therapy was evaluated in 2 experiments
using the V. parahaemolyticus CRS 09-17 infection mouse
model. In the first experiment, 2 groups of mice (control/treatment;
5 mice in each group) were challenged by an IP injection
of an LD50 of CRS 09-17. Each mouse was treated with a single
IP injection of phage pVp-1 (2.0 × 108 PFU per mouse) or PBS
1 hour after the bacterial challenge (2.0 × 107 CFU per mouse).