Tungstate was orally administered to 7.5-week-old male Zucker diabetic fatty (ZDF) rats that already showed moderate hyperglycemia (180 ± 16 mg/dl). The animals became normoglycemic for ∼10 days. Then, glycemia started to rise again, although it did not reach the initial values until day 24, when levels stabilized at ∼200 mg/dl for the duration of the experiment. Untreated ZDF rats showed steadily increased blood glucose levels between 7.5 and 10 weeks of age, when they reached a maximum value of 450 ± 19 mg/dl, which was maintained throughout the experiment