Abstract: The aim of this work was to study the effect of dynamic maceration
factors upon the curcumin content of Curcuma longa L., Zingiberaceae, extracts and
to determine the optimum set of parameters for the extraction of curcumin using a
25 full factorial design and the response surface methodology. Under the established
conditions, the content of soluble solids and curcumin in the extracts ranged from 0.8
to 3.4%, and from 0.1 to 1.8%, respectively. The most influential variable observed
for the extraction was the ethanolic strength of the solvent. The optimized condition
involves an extraction time of 12 h, agitation speed of 30 rpm, drug to solvent
ratio of 1/6, extraction temperature of 80 ºC and the solvent with ethanolic strength
of 70%. The data reported herein are useful for further developments of curcuma
phytopharmaceutical intermediate products with optimized characteristics.
Abstract: The aim of this work was to study the effect of dynamic maceration
factors upon the curcumin content of Curcuma longa L., Zingiberaceae, extracts and
to determine the optimum set of parameters for the extraction of curcumin using a
25 full factorial design and the response surface methodology. Under the established
conditions, the content of soluble solids and curcumin in the extracts ranged from 0.8
to 3.4%, and from 0.1 to 1.8%, respectively. The most influential variable observed
for the extraction was the ethanolic strength of the solvent. The optimized condition
involves an extraction time of 12 h, agitation speed of 30 rpm, drug to solvent
ratio of 1/6, extraction temperature of 80 ºC and the solvent with ethanolic strength
of 70%. The data reported herein are useful for further developments of curcuma
phytopharmaceutical intermediate products with optimized characteristics.
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