Single-agent or combination treatment of metastatic carcinoma of the colon or rectum (previously untreated or recurred/progressed after 5-FU-based therapy), non-small-cell or small-cell lung cancer. In combination w/ 5-FU, folinic acid & bevacizumab for 1st-line metastatic carcinoma of colon or rectum. Cervical, ovarian & esophageal cancer; inoperable or recurrent gastric cancer. As single agent for treatment of glioma. In combination w/ cetuximab for treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer after failure of irinotecan-containing therapy