On the other hand, HPP is not effective as a kill step against all microbial forms. Spore-forming organisms are highly resistant to HPP when they are in their spore form, and a combination of pressure and heat, or some other antibacterial intervention, is required to achieve any reduction
of bacterial spores in foods. Of particular concern are spores of the organism Clostridium botulinum, which can germinate, grow, and produce a highly potent paralytic neurological toxin in low acid foods.