Sixty-five dogs (27males, 28 females; age range:
6months to 6 years; weight range: 8.3 to 11.2kg) with
naturally acquired infestations of S. scabiei were used
in these studies. The animals presented clinical signs
of sarcoptic mange including, erythematous lesions,
crusts, alopecia, hyperkeratosis and intense pruritis.
The dogs were of various breeds, mainly mongrels
were otherwise healthy at veterinary assessment on
Day -7. Animals selected for the studies had not received
any avermectin or milbemycin drugs nor had
they been treated with an ectoparasiticide for at least
60 days prior to the first administration of treatment.
Dogs were housed individually under strict quarantine
measures in pens that were approximately 3.7 m ×1.7
m with concrete flooring. The indoor sleeping area
had under floor heating and the outdoor run area was
covered to prevent exposure to rain. No contact between
dogs was possible. The dogs were acclimated to
the study conditions for 7 days prior to treatment, and
were observed for general health at least once daily for
the duration of the study.