Variation in the nuclear shape and size was characteristic finding in this work and explained by some authors that increased nuclear area is often observed in compounds that block cell cycle and induce DNA damage [28].
Bcl-2 is an apoptosis-related molecule that was shown to be down-regulated during the early events leading to programmed cell death and its protein might be as an inhibiting molecule and play an important role in the balance between apoptosis promotion and inhibition