The enviMass workflow (version 1.0) [15] was applied to pro-cess the peak lists. For the two batches of experiments with riverRoter Main sediment – for which a blank-control experimentwas available – the peak lists of the incubations that containedpharmaceuticals and the corresponding blank-control at the samesampling time were simultaneously imported into enviMass andthe blank subtraction routine was applied (tolerance windows:m/z: ±5 mDa; RT: ±0.05 min).