The comparison results suggest that CDLC performs better than the other five methods (DC, LAC, SoECC, PeC, and CoEWC). Particularly, CDLC can achieve more than 45% improvement in prediction precision compared with DC. We also compare CDLC with the latest essential protein predicting approach named CEPPK (Li et al., 2014), and results show that CDLC outperforms CEPPK.