In the present paper, hydroxypropyl cellulose (HPC) is
investigated as a backbone for “grafting from” polymerization under ATRP conditions to produce comb polymers. Moreover, dendronization of the hydroxypropyl cellulose using bis-MPA dendrons and subsequent ATRP grafting from the surface of the dendronized polymer was studied. The advantage of using HPC is the available hydroxyl groups, which show high reactivity with bis-MPA derivatives combined with the improved solubility HPC exhibits as compared to native cellulose. Furthermore, bis-MPA and HPC are both biocompatible, which could make these dendronized polymers promising candidates for biomedical applications.