Conclusions
Over the last decade, major breakthroughs in nanotech nology have been achieved. It is only a matter of time before new nano based drugs reach respiratory medicine.Especially the fields of targeted drug delivery, gene ther apy, and hyperthermia offer great potential for modern drugs. On the other hand the increased use of nanoma terials in all fields of life also bears the risk of exposure through inhalation. It is therefore essential to understand pulmonary toxicology of nanomaterials in all its facets. However, it is still very unclear why the toxic ef fects of nanoparticles in the respiratory tract are so in homogeneous and not well predictable. In this context,not only local reactions of lung and airways but also nanoparticle uptake and distribution in the organism are important factors and therefore fields of current research. As only few nanoparticle compositions have been tested, it is questionable whether those results can be easily adapted to other nanoparticles. Because of the continuously increasing diversity of engineered nanopar ticles, toxicology can hardly keep pace with the safety as sessment of future products. Therefore, more attention should be set on this wide field of research