distribution ratio of EC was higher than C, which agrees well
with the previous results of C and EC acrossing BBB cells in
vitro. C and EC rapidly (within 20 min) crossing the BBB and
entering the extracellular fluid of the hippocampus after iv
administration demonstrated a substantial basis for the
therapeutic effect on brain diseases and provided scientific
proof for rational administration. The BBB penetration
mechanisms of C and EC (such as how or in what form they
passed through the BBB) and the pharmacokinetic profiles of
metabolites are under investigation in our laboratory.