Cephalexin (CLX) is a first-generation cephalosporin antimicrobial with high water solubility (>1789 mg L1) and is widely used for therapeutic purposes (Tsai et al., 2000). The effluent concentration of CLX from a cephalosporin factory after treatment has reported as 29 mg L1 in India (Sundararaman and Saravanane,2010). As a bacteriostatic antimicrobial, Erythromycin (ERY) belongs to macrolides which represent the second largest consumption of antimicrobials behind b-lactams (Anton Kovácˇik,2012). ERY is the most commonly used macrolides in human medicine and also the parent compound of another two common antimicrobials-azithromycin and clarithromycin (Amsden, 1996). Tetracycline (TC) is a broad-spectrum antimicrobial which and