As for the
Clarke’s work, the cleaving on a single stranded DNA molecule
into single nucleotide by exonuclease is conducted
inside the cis side solution far from the pore area so the sequencing
on a DNA molecule cannot be given accurately,
and the composition or the proportion of four nucleotides can only be shown. For the Chen’s work, the reproductively
is still questioned and the data validity is now under investigation
from editorial note