Results: Sixty seven patients (45.9%) died during the follow-up period. The median age of patients was
14.2 years and ranged from 9.3 to 38.7 years. The median follow-up time was 29.6 months (range 5 to 60
months). Individuals with GSTP1 G/G genotype tended to live shorter than A/A genotype, and we found
a significantly higher risk of death from osteosarcoma (adjusted HR=2.73, 95% CI=1.05-7.45). Individuals
with the GSTP GG genotype were more likely to have a poor response to chemotherapy, with an OR of
2.73 (95%CI, 1.07-7.81). However, we did not find association of polymorphisms in GSTM1 and GSTT1 with
response to chemotherapy and prognosis of osteosarcoma