Numerousrandomizedtrials evaluatingduration of dual antiplatelet therapy after coronary stenting have demonstrated a trade-offbetweenreductions in ischemiaandincreases in bleeding associated with longer durations of treatment.19-23 Although clinical trial results are expected to be applied to the population represented by enrollment criteria, in the setting of discordant risksandbenefits of treatment, tailoring therapies to individual patient profiles to maximize benefits and minimize harms affords an opportunity to further optimize outcomes