The soy diet reduced growth of transplantable prostate
adenocarcinomas and inhibited tumor cell proliferation
and angiogenesis of transplantable prostate
cancer in immunodeficient mice [93,94]. A diet rich
in soy also inhibited pulmonary metastasis of melanoma cells in C57Bl/6 mice [95]. Genistein inhibited the growth of carcinogen-induced cancers in rats and human leukemia cells transplanted into mice
[87,88,96,97]. Singh et al. [98] evaluated the natural
form of genistein, and the isoflavone-rich soy phytochemical concentrate (SPC) on the growth and
metastasis of human bladder cancer cells 253J BVinduced tumors in an orthotopic site. Both treatment
regimes were effective in reducing tumor
weight by more than 50%, accompanied by induction
of tumor cell apoptosis and inhibition of tumor
angiogenesis in vivo. However, SPC treatment was
significantly better, which inhibited lung metastases
by 95% and reduced circulating insulin-like growth
factor-I levels [98].