Dietary supplementation of antioxidant-rich berries (e.g., blueberry, strawberry) can positively affect cognition and memory in the
aged animal[33]. Cyanidin-3-O-glucopyranoside (Cy-3G), an anthocyanin that abundant in colorful vegetables and fruits, has recently
been identified as neuroprotective phytochemicals. It decreases Aβ
peptide-mediated cytotoxicity in SH-SY5Y neurocytes[34]. Cy-3G
also could reduce cerebral ischemia and ageing-related neuronal
deficits in animal model[35]. Dietary supplementation with anthocyanin-richVaccinium myrtillisL. suppresses stress-induced protein
carbonyl formation and lipid oxidation in the brain [36]. Dietary
supplementation withVacciniumspp. (blueberry) for consecutive 12
weeks also shows enhancing effects on spatial working memory test
in aged rats (21-month-old) through cAMP-response elementbinding protein and brain-derived neurotrophic factor pathways
[37]. Furthermore, blackcurrant, which is known to be rich in
anthocyanins, is already used as food additive and has been shown