Rosiglitazone and pioglitazone are generally well tolerated
As noted in section 3.2.3,aution is advised in heart disease;in the UK this includes a history of cardiac failure,oedema,anaemia and liver function requiring intermittent monitoring in accordance with the package labelling.
If contraindications arise during treatment,monitoring should be intensified and,if necessary, treatment discontinued.
Hypoglycaemia may occur several weeks after adding a thiazolidinedione to a sulphonylurea;selfmonitoring of blood glucose can be helpful in identifying the pointt at which the dosage of the sulphonylurea should bereduced.