plasma levels of Ac-5-ASA did not correlate with either transit times through the small intestine, with the consumption of breakfast or the extent of dispersion within the colon. when time of the peak plasma concentration at that time, almost all the granules were located in small intestine or ascending colon (Table IV). The peak Ac-5-ASA concentration tended to occur more frequently while all the microgranules were in the small intestine on the occasions when the preparation was taken without breakfast