The present research work could be concluded as successful production of SLNs using GMS as a solid lipid by solvent - injection technique. Further, developed SLNs were meaningfully utilized for the topical delivery of lipophilic, anti-psoriatic drug, MF. Greater skin deposition and slow drug release was observed with the developed SLN. SLN topical gel containing MF would be advantageous over the marketed cream product. Production of MF loaded SLNs and its formulation as a topical gel could be a new, cost-effective and commercially viable alternative to the marketed product