The CBZ EC tended to increase with the addition of albumin to dialysate (Table 3). In four of the 12 blood flow/dialysate flow/dialyzer combinations, the 5% albumin dialysate resulted in a significantly higher EC than was seen with the 2.5% albumin dialysate. As with the other drugs, no consistent effect on CBZ EC was noted with changes in Qb. Increasing Qd tended to lower the CBZ EC regardless of dialysate type, particularly with the AN69 hemodialyzer. The CBZ EC using control dialysate did not differ much be- tween filter types, regardless of Qb and Qd. Interestingly, the CBZ EC values between filter types differed consid- erably once albumin was added to the dialysate. At low Qd with albumin-containing dialysates, the AN69 CBZ EC trend was higher than those generated with the polysul- fone dialyzers, but at higher Qd with albumin-containing dialysates; the CBZ EC were considerably higher with the polysulfone hemodialyzers.
Overall, the addition of albumin to dialysate tended to lower PHT EC in contrast to our hypothesis (Table 4). In- creasing Qb tended to increase PHT EC with the control dialysate; however, changes in Qb had no consistent in- fluence once albumin was added to dialysate. Increasing the Qd had no consistent effect on PHT EC. When control dialysate was used, the PHT EC was consistent and did not differ between dialyzer types. Albumin added to dialysate resulted in the larger polysulfone hemodialyzer having